Genetic Engineering of T Cells for Immune Tolerance

Regulatory T Cells and Immune Tolerance

Regulatory T cells (Tregs) play an indispensable role in maintaining immunological unresponsiveness to self-antigens and in suppressing excessive immune responses deleterious to the host. Tregs are produced in the thymus as a functionally mature subpopulation of T cells and can also be induced from naive T cells in the periphery. Recent research reveals the cellular and molecular basis of Treg ...

role of b cells in immune tolerance

T cells expressing chimeric antigen receptor promote immune tolerance.

Cellular therapies based on permanent genetic modification of conventional T cells have emerged as a promising strategy for cancer. However, it remains unknown if modification of T cell subsets, such as Tregs, could be useful in other settings, such as allograft transplantation. Here, we use a modular system based on a chimeric antigen receptor (CAR) that binds covalently modified mAbs to contr...

Induced CD4+Foxp3+ regulatory T cells in immune tolerance.

Regulatory T lymphocytes are essential to maintain homeostasis of the immune system, limiting the magnitude of effector responses and allowing the establishment of immunological tolerance. Two main types of regulatory T cells have been identified--natural and induced (or adaptive)-and both play significant roles in tuning down effector immune responses. Adaptive CD4(+)Foxp3(+) regulatory T (iTr...

Immune Tolerance by Induced Regulatory T Cells in Asthma

© Copyright The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease http://e-aair.org Dr. Ralph M. Steinman, who discovered the dendritic cells (DCs) that play a key role in the adaptive immune response, was awarded the 2011 Nobel Prize in Physiology or Medicine 3 days after his untimely death. Dr. Steinman used autologous ...